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Amygdala electrical-finger-print (AmygEFP) NeuroFeedback guided by individually-tailored Trauma script for post-traumatic stress disorder: Proof-of-concept.

par Fruchtman-Steinbok, Tom;Keynan, Jackob JN;Cohen, Avihay;Jaljuli, Iman;Mermelstein, Shiri ;Drori, Gadi;Routledge, Efrat;Krasnoshtein, Michael;Playle, Rebecca;Linden, David E J;Hendler, Talma
Référence NeuroImage: Clinical, 32, page (102859)
Publication Publié, 2021-02-01

Article révisé par les pairs

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Résumé :

Amygdala activity dysregulation plays a central role in post-traumatic stress disorder (PTSD). Hence learning to self-regulate one's amygdala activity may facilitate recovery. PTSD is further characterized by abnormal contextual processing related to the traumatic memory. Therefore, provoking the personal traumatic narrative while training amygdala down-regulation could enhance clinical efficacy. We report the results of a randomized controlled trial (NCT02544971) of a novel self-neuromodulation procedure (i.e. NeuroFeedback) for PTSD, aimed at down-regulating limbic activity while receiving feedback from an auditory script of a personal traumatic narrative. To scale-up applicability, neural activity was probed by an fMRI-informed EEG model of amygdala activity, termed Amygdala Electrical Finger-Print (AmygEFP).