Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children.

Strollo, Rocky; Vinci, Chiara; Napoli, Nicola; Pozzilli, Paolo; Ludvigsson, Johnny; Nissim, Ahuva

doi:doi/10.1007/s00125-017-4296-1

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Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children.

par Strollo, Rocky ;Vinci, Chiara

;Napoli, Nicola ;Pozzilli, Paolo ;Ludvigsson, Johnny ;Nissim, Ahuva
Référence Diabetologia, 60, 8, page (1467-1474)
Publication Publié, 2017

Article révisé par les pairs

Résumé :

We have shown that autoimmunity to insulin in type 1 diabetes may result from neoepitopes induced by oxidative post-translational modifications (oxPTM). Antibodies specific to oxPTM-insulin (oxPTM-INS-Ab) are present in most newly diagnosed individuals with type 1 diabetes and are more common than autoantibodies to native insulin. In this study, we investigated whether oxPTM-INS-Ab are present before clinical onset of type 1 diabetes, and evaluated the ability of oxPTM-INS-Ab to identify children progressing to type 1 diabetes.

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