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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.

par Demine, Stéphane ;Schiavo, Andréa Alex ;Marin Canas, Sandra ;Marchetti, Piero;Cnop, Miriam ;Eizirik, Decio L.
Référence Stem cell research & therapy, 11, 1, page (7)
Publication Publié, 2020

Article révisé par les pairs

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Résumé :

Adult human pancreatic beta cells are the "gold standard" for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has recently taken place to differentiate beta cells from human induced pluripotent stem cells (iPSCs) and validate their use for diabetes research. We presently used a 7-stage protocol to generate beta cells from human iPSC and evaluated whether these cells are responsive to the pro-inflammatory cytokines (IFNγ, IL-1β, or IFNα) that play a role in type 1 diabetes.