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Metformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis

par Kefas, Benjamin Ate;Cai, Ying ;Kerckhofs, Karen;Ling, Zhidong;Martens, Geert A;Heimberg, Harry;Pipeleers, Daniel;Van De Casteele, Christine
Référence Biochemical pharmacology, 68, 3, page (409-416)
Publication Publié, 2004-08

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Titre:	Metformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis
Auteur:	Kefas, Benjamin Ate; Cai, Ying; Kerckhofs, Karen; Ling, Zhidong; Martens, Geert A; Heimberg, Harry; Pipeleers, Daniel; Van De Casteele, Christine
Informations sur la publication:	Biochemical pharmacology, 68, 3, page (409-416)
Statut de publication:	Publié, 2004-08
Sujet CREF:	Biochimie
	Pharmacologie
Mots-clés:	β-cell metabolism
	5-amino-imidazole-4-carboxamide- riboside
	ACC
	acetyl coA carboxylase
	AICA-riboside
	AICAR
	AMP-activated protein kinase
	AMPK
	Apoptosis
	c-Jun-N-terminal kinase
	Diabetes
	JNK
	Metformin
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0006-2952
	info:doi/10.1016/j.bcp.2004.04.003
	info:pii/S0006295204002345
	info:scp/3042702709
	info:pmid/15242807