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Resting-state functional brain connectivity is related to subsequent procedural learning skills in school-aged children

par Van Dyck, Dorine ;Deconinck, Nicolas ;Aeby, Alec ;Baijot, Simon ;Coquelet, Nicolas ;Trotta, Nicola ;Rovai, Antonin ;Goldman, Serge ;Urbain, Charline ;Wens, Vincent ;De Tiege, Xavier
Référence NeuroImage, 240, page (118368)
Publication Publié, 2021-07-06

Article révisé par les pairs

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Résumé :

This magnetoencephalography (MEG) study investigates how procedural sequence learning performance is related to prior brain resting-state functional connectivity (rsFC), and to what extent sequence learning induces rapid changes in brain rsFC in school-aged children. Procedural learning was assessed in 30 typically developing children (mean age ± SD: 9.99 years ± 1.35) using a serial reaction time task (SRTT). During SRTT, participants touched as quickly and accurately as possible a stimulus sequentially or randomly appearing in one of the quadrants of a touchscreen. Band-limited power envelope correlation (brain rsFC) was applied to MEG data acquired at rest pre- and post-learning. Correlation analyses were performed between brain rsFC and sequence-specific learning or response time indices. Stronger pre-learning interhemispheric rsFC between inferior parietal and primary somatosensory/motor areas correlated with better subsequent sequence learning performance and faster visuomotor response time. Faster response time was associated with post-learning decreased rsFC within the dorsal extra-striate visual stream and increased rsFC between temporo-cerebellar regions. In school-aged children, variations in functional brain architecture at rest within the sensorimotor network account for interindividual differences in sequence learning and visuomotor performance. After learning, rapid adjustments in functional brain architecture are associated with visuomotor performance but not sequence learning skills.