par Tommelein, J.;Verset, Laurine 
;Boterberg, Tom;Demetter, Pieter ;Bracke, Marc E.;De Wever, Olivier
Référence Frontiers in oncology, 5, 63
Publication Publié, 2015-01
;Boterberg, Tom;Demetter, Pieter ;Bracke, Marc E.;De Wever, OlivierRéférence Frontiers in oncology, 5, 63
Publication Publié, 2015-01
Article révisé par les pairs
| Résumé : | Colorectal cancer (CRC) progression and eventually metastasis is directed in many aspects by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer-associated fibroblasts (CAFs), endothelial cells, and diverse immune cells. CAFs are recruited from local tissue-resident fibroblasts or pericryptal fibroblasts and distant fibroblast precursors. CAFs are highly abundant in CRC. In this review, we apply the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan andWeinberg. CAFs influence innate and adaptive tumor immune responses. Using datasets from previously published work, we re-explore the potential messages implicated in this process. Fibroblasts present in metastasis (metastasis-associated fibroblasts) from CRC may have other characteristics and functional roles than CAFs in the primary tumor. Since CAFs connect metastasis-promoting communication, CAF markers are potential prognostic biomarkers. CAFs and their products are possible targets for novel therapeutic strategies. |
