SWOTein: a structure-based approach to predict stability Strengths and Weaknesses of prOTEINs.

Hou, Qingzhen; Pucci, Fabrizio; Ancien, François; Kwasigroch, Jean-Marc; Bourgeas, Raphaël; Rooman, Marianne

doi:doi/10.1093/bioinformatics/btab034

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SWOTein: a structure-based approach to predict stability Strengths and Weaknesses of prOTEINs.

par Hou, Qingzhen

;Pucci, Fabrizio

;Ancien, François

;Kwasigroch, Jean-Marc

;Bourgeas, Raphaël

;Rooman, Marianne

Référence Bioinformatics
Publication Publié, 2021-01

Article révisé par les pairs

Résumé :

Although structured proteins adopt their lowest free energy conformation in physiological conditions, the individual residues are generally not in their lowest free energy conformation. Residues that are stability weaknesses are often involved in functional regions, whereas stability strengths ensure local structural stability. The detection of strengths and weaknesses provides key information to guide protein engineering experiments aiming to modulate folding and various functional processes.

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