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AlphaFold2 predicts the inward-facing conformation of the multidrug transporter LmrP

par del Alamo, Diego;Govaerts, Cédric ;Mchaourab, Hassane H.S.
Référence Proteins
Publication Publié, 2021-11-01

Article révisé par les pairs

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Résumé :

As part of the CASP competition, the protein structure prediction algorithm AlphaFold2 generated multiple models of the proton/drug antiporter LmrP. Previous distance restraints from double electron-electron resonance spectroscopy, a technique which reports distance distributions between spin labels attached to proteins, suggest that one of the lower-ranked models may have captured a conformation that has so far eluded experimental structure determination.