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Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma with a BRAF Mutation: A Case Report

par Catteau, Xavier ;Preat, Fanny;D'Haene, Nicky ;Noël, Jean Christophe
Référence International journal of gynecological pathology
Publication Publié, 2020-03-01

Article révisé par les pairs

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Résumé :

A 44-yr-old woman presented with lower, painless abdominal discomfort and a vacuolated mass measuring 12 cm on the right-hand side of the pelvis. She subsequently underwent a bilateral salpingo-oophorectomy. An osseous lesion was identified in the left ovary, which was hard in consistency and was associated with a multicystic complex. Microscopic examination of the left ovary showed clusters of serous cells with moderate atypia, surrounded by a desmoplastic stroma with large areas of bone matrix. To the best of our knowledge, this is the first reported case of low-grade serous carcinoma with osseous metaplasia and a BRAF mutation.