Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells.

El-Kehdy, Hoda; Najar, Mehdi; De Kock, Joery; Moussa Agha, Douaa; Rogiers, V; Merimi, Makram; Lagneaux, Laurence; Sokal, Etienne M; Najimi, Mustapha

doi:doi/10.3390/cells9071640

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Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells.

par El-Kehdy, Hoda ;Najar, Mehdi

;De Kock, Joery ;Moussa Agha, Douaa

;Rogiers, V ;Merimi, Makram

;Lagneaux, Laurence

;Sokal, Etienne M ;Najimi, Mustapha
Référence Cells, 9, 7
Publication Publié, 2020-12-01

Article révisé par les pairs

Résumé :

The progression of mesenchymal stem cell-based therapy from concept to cure closely depends on the optimization of conditions that allow a better survival and favor the cells to achieve efficient liver regeneration. We have previously demonstrated that adult-derived human liver stem/progenitor cells (ADHLSC) display significant features that support their clinical development. The current work aims at studying the impact of a sustained pro-inflammatory environment on the principal biological features of ADHLSC in vitro.

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