• Citer

Model informed dosing of hydroxycholoroquine in COVID-19 patients: Learnings from the recent experience, remaining uncertainties and gaps.

par Thémans, Pauline;Dauby, Nicolas ;Schrooyen, Loic ;Lebout, Faustine;Delforge, Marie-Luce ;Nasreddine, Rakan ;Libois, Agnès ;Payen, Marie-Christine ;Konopnicki, Deborah ;Wuillaume, Françoise;Lescrainier, Cecile;Verlinden, Veerle;Dogné, Jean-Michel;Hamdani, Jamila ;Musuamba, Flora T
Référence British journal of clinical pharmacology
Publication Publié, 2020-06

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

In the absence of a commonly agreed dosing protocol based on pharmacokinetic (PK) considerations, the dose and treatment duration for hydroxychloroquine (HCQ) in COVID-19 disease currently vary across national guidelines and clinical study protocols. We have used a model-based approach to explore the relative impact of alternative dosing regimens proposed in different dosing protocols for hydroxychloroquine in COVID-19.