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Résumé : ObjectivesTo prospectively assess the contribution of different factors in the visualisation of embryonic anatomy between 8 and 10+6 week's gestation (WG) in a low‐risk population.MethodsThe study protocol on sonoembryology was approved by the local ethic committee. In our tertiary center, all pregnant women below 11 WG underwent a transvaginal ultrasound for an early anatomical assessment of embryonic anatomy. A single fetal medicine specialist performed all the examinations, previous a written informed consent by the patient. Multivariable logistic regression analysis was used in order to investigate the effect on the ability to visualise separately: brain, eyes, superior lip, four‐chamber view, outflow tracts, arms and legs, stomach, kidneys, spine and bladder. The following parameters were tested as continuous numerical variables: fetal crown–rump length (CRL (mm), maternal body mass index (BMI (kg/m2), distance between the transducer and the crux of the heart (mm). The parity and the position of the placenta (between or not between the ultrasound beam and the embryo) were tested as categorical variables.ResultsFrom October 2011 to December 2013; 1318 consecutives patients with a live embryo pregnancy between 16 mm and 44 mm of CRL were enrolled in this prospective study. Regression analysis showed that the ability to visualise heart anatomy, brain, arms and legs depends on the CRL and on the distance between the probe and the embryo. The ability to visualize the face, the stomach, the kidneys and the spine depends on the CRL, the distance between the probe and the embryon, the parity and the position of the placenta. According to GA, percentage of visualisation for different anatomical parts was also evaluated.ConclusionsSonographic assessment of human embryo anatomy can be performed as early as 8 WG. CRL and distance between the probe and embryo are the most important factor influencing visualisation of embryon anatomy.