Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Bugliani, M.; Mossuto, Sandra; Grano, Francesca; Suleiman, Mara; Marselli, L.; Boggi, U.; De Simone, Paolo; Eizirik, Decio L.; Cnop, Miriam; Marchetti, P.; De Tata, Vincenzo

doi:doi/10.3389/fendo.2019.00052

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Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

par Bugliani, M.;Mossuto, Sandra ;Grano, Francesca ;Suleiman, Mara ;Marselli, L.;Boggi, U.;De Simone, Paolo

;Eizirik, Decio L.

;Cnop, Miriam

;Marchetti, P.;De Tata, Vincenzo
Référence Frontiers in endocrinology, 10, page (52)
Publication Publié, 2019

Article révisé par les pairs

Résumé :

Autophagy is the major mechanism involved in degradation and recycling of intracellular components, and its alterations have been proposed to cause beta cell dysfunction. In this study, we explored the effects of autophagy modulation in human islets under conditions associated to endoplasmic reticulum (ER) stress. Human pancreatic islets were isolated by enzymatic digestion and density gradient purification from pancreatic samples of non-diabetic (ND; n

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