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Allergic rhinitis and nasal provocation: Correlation among objective symptoms, mediators, and eosinophils during the early- and late-phase reaction after nasal provocation in allergic patients

par Clement, Péter ;Wang, De Yun
Référence Pediatric Nasal and Sinus Disorders, CRC Press, page (117-125)
Publication Publié, 2005-01

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Résumé :

Today, the most commonly used sample technique to collect nasal secretions is the nasal lavage technique. With this technique it has been only possible to give qualitative data because of an unknown dilution factor. Biewenga et al. (1) designed a new aspiration system to evaluate protein and immunoglobuline concentrations in human nasal secretions. This direct aspiration system combines the advantages of minimal irritation of the nasal mucosa with the convenience of determine mediator concentrations per gram of secretion. With this technique in mind the authors tried to determine the exact concentrations of selected mediators in the nasal secretions by using the nasal microsuction technique before and after nasal allergen challenge (NAC). It was also attempted to correlate this quantitative data with objective nasal symptoms. In 10 normal test subjects they found the following concentrations for five different mediators: histamine 19 ng/g (range 7.5-32), tryptase 0.0 mU/g (range 0-11), leukotriene C4 (LTC4) 5.7 ng/g (range 3.6-13), prostaglandin D2 (PGD2) 477 pg/g (range 220-788), and eosinophil cationic protein (ECP) 105 ng/g (range 2-281).