par Nizet, Y;Chentoufi, A A;de la Parra, B;Lewalle, Philippe
;Rouas, Redouane
;Cornet, A;Besse, T;Mourad, M;Malaise, Justine
;Squifflet, Jean-Paul;Bazin, Hervé;Latinne, Dominique
Référence Transplantation, 69, 7, page (1420-1428)
Publication Publié, 2000-04



Référence Transplantation, 69, 7, page (1420-1428)
Publication Publié, 2000-04
Article révisé par les pairs
Résumé : | CD2 is a cell surface glycoprotein expressed on most human T cells and natural killer (NK) cells, working as a cell adhesion and costimulatory molecule. The aim of this paper is to analyze the mechanism of action of a rat IgG2b anti-human CD2 monoclonal antibody (mAb) (LO-CD2a/BTI-322 mAb), which is a potent immunosuppressive agent and inducer of cell death. In vivo, this mAb is able to prevent or treat kidney allograft rejection. |