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Continuous Flow Chlorination of Alkenyl Iodides Promoted by Copper Tubing

par Nitelet, Antoine ;Kairouz, Vanessa;Lebel, Hélène;Charette, André B.;Evano, Gwilherm
Référence Synthesis, 51, page (251-257)
Publication Publié, 2019-01-01

Article révisé par les pairs

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Résumé :

A simple continuous flow synthesis of alkenyl chlorides from the corresponding readily available alkenyl iodides in a copper reactor tubing is described. A variety of alkenyl chlorides were obtained in good to excellent yields with full retention of the double bond geometry. The reaction time was reduced by a factor of 24 to 48 compared to the batch process.