PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-alpha and-gamma via IRF1 induction.

Colli, Maikel Luis; Hill, Jessica L E; Marroquí, Laura; Chaffey, Jessica; Dos Santos, Reinaldo Sousa; Leete, Pia; Coomans De Brachene, Alexandra; Paula, Flavia M M; Op De Beeck, Anne; Castela, Angela; Marselli, Lorella; Krogvold, Lars; Dahl-Jorgensen, Knut; Marchetti, Piero; Morgan, Noel G; Richardson, Sarah J; Eizirik, Decio L.

doi:doi/10.1016/j.ebiom.2018.09.040

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Article révisé par les pairs

Résumé :

Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and how is it regulated.

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