• Citer

Explaining the geographic spread of emerging epidemics: a framework for comparing viral phylogenies and environmental landscape data

par Dellicour, Simon ;Rose, Rebecca;Pybus, Oliver George
Référence BMC bioinformatics, 17, page (82)
Publication Publié, 2016-02-11

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Phylogenetic analysis is now an important tool in the study of viral outbreaks. It can reconstruct epidemic history when surveillance epidemiology data are sparse, and can indicate transmission linkages among infections that may not otherwise be evident. However, a remaining challenge is to develop an analytical framework that can test hypotheses about the effect of environmental variables on pathogen spatial spread. Recent phylogeographic approaches can reconstruct the history of virus dispersal from sampled viral genomes and infer the locations of ancestral infections. Such methods provide a unique source of spatio-temporal information, and are exploited here.