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ANTICORPS ANTI-CELLULES DES ILOTS DE LANGERHANS ET SPECIFIQUES D'ORGANES CHEZ LES JEUNES DIABETIQUES. RELATION AVEC L'AGE, LE DEBUT ET LA DUREE DU DIABETE, LA SECRETION RESIDUELLE D'INSULINE ET LA RETINOPATHIE

par Dorchy, Harry ;Lemiere, B;Toussaint, Daniel ;Gausset, Philippe
Référence Nouvelle Presse Medicale, 10, 34, page (2795-2798)
Publication Publié, 1981

Article révisé par les pairs

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Résumé :

The prevalence of islet-of-Langerhans-cell antibodies and of 10 organ-specific antibodies was determined in 71 diabetic children and adolescents whose mean duration of diabetes was 4 1/2 years. Forty-four per cent of the patients had autoantibodies: 15% had islet-cell antibodies and 31% had organ-specific antibodies. The prevalence of antinuclear, gastric parietal cell and striated muscle antibodies was significantly higher in diabetics than in controls. There was no relationship between prevalence of antibodies and age of the diabetics nor age at the onset of the disease. The frequency of circulating islet-cell antibodies tended to decrease with the duration of diabetes, while organ-specific antibodies remained stable. The study failed to demonstrate any correlation between measurable C-peptide and the presence of autoantibodies. Diabetic retinopathy, diagnosed by fluorescein angiography, was not related to the presence of autoantibodies.