par Famaey, Jean Pierre
Référence Journal Belge de Rhumatologie et de Medicine Physique, 29, 1, page (23-33)
Publication Publié, 1974
Article révisé par les pairs
Résumé : After describing some classical impaired reactions to the most common antirheumatic drugs, the author tries to give an answer to the question: is it possible that most of the well known secondary effects of the non steroidal antiinflammatory drugs (NSAID) are related to the mode of action of these drugs? The present biochemical concepts about the antiinflammatory and analgesic proporties of these drugs are quoted and the author emphasizes their membrane properties (mitochondrial and lymphocytes swelling, stimulation of various ion movements) which could be related to some of their analgesic actions. Three of the most classical iatrogenic aspects of these drugs could also be related to their membrane effects: gastrointestinal disturbances (for which the author also quotes other hypotheses), the effects on the hydrosaline and kidney metabolism and the effects on blood platelets. Finally after having speculated on possible relationships between these membrane properties and some other secondary effects the author gives his point of view concerning the way to avoid such iatrogenic reactions. Forty three references are cited.