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L'HYPO-URICEMIE DANS LE SYNDROME DE SECRETION INAPPROPRIEE D'HORMONE ANTIDIURETIQUE

par Ducobu, Jean ;Dupont, Pierre
Référence Nouvelle Presse Medicale, 11, 12, page (915-916)
Publication Publié, 1982

Article révisé par les pairs

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Résumé :

A retrospective study of 22 patients with hyponatremia (<130 mEq/l) was conducted to find out whether hypouricemia was useful in the diagnosis of SIADH. Serum levels of uric acid were inferior to 38 mg/l in 9 out of 12 patients with SIADH but not in the remaining 10 patients without SIADH. The mechanism of hypouricemia in the syndrome seems to be an increase in uric acid excretion, since water restriction reduces the fractional clearance of urates. The authors conclude that hypouricemia appears to constitute a reliable means of detecting SIADH in patients with hyponatremia.