• Citer

Esmolol Administration to Control Tachycardia in an Ovine Model of Peritonitis.

par Hosokawa, Koji ;Su, FUHONG ;Taccone, Fabio ;Post, Elmar ;Pereira, Adriano José;Herpain, Antoine ;Creteur, Jacques ;Vincent, Jean Louis
Référence Anesthesia and analgesia, 125, 6, page (1952-1959)
Publication Publié, 2017

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Excessive adrenergic signaling may be harmful in sepsis. Using β-blockers to reduce sympathetic overactivity may modulate sepsis-induced cardiovascular, metabolic, immunologic, and coagulation alterations. Using a randomized ovine fecal peritonitis model, we investigated whether administration of a short-acting β-blocker, esmolol, could control tachycardia without deleterious effects on hemodynamics, renal perfusion, cerebral perfusion, cerebral metabolism, or outcome.