par Ghesquière, Jonathan 
;Marcelis, Lionel ;Moucheron, Cécile ;Kirsch-De Mesmaeker, Andrée ;Le Gac, Stéphane
Référence Current topics in medicinal chemistry, Vol. 12, page (185-196)
Publication Publié, 2012
;Marcelis, Lionel ;Moucheron, Cécile ;Kirsch-De Mesmaeker, Andrée ;Le Gac, StéphaneRéférence Current topics in medicinal chemistry, Vol. 12, page (185-196)
Publication Publié, 2012
Partie d'ouvrage collectif
| Résumé : | Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for RuII polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of RuII polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing RuII complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed. © 2012 Bentham Science Publishers. |
