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Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.

par Gurzov, Esteban Nicolas ;Tran, Melanie;Fernandez-Rojo, Manuel MA;Merry, Troy TL;Zhang, Xinmei;Xu, Yang;Fukushima, Atsushi;Waters, Jonathan Michael;Watt, Matthew J;Andrikopoulos, Sofianos;Neel, Benjamin BG;Tiganis, Tony
Référence Cell Metabolism, 20, 1, page (85-102)
Publication Publié, 2014-07

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Titre:	Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.
Auteur:	Gurzov, Esteban Nicolas; Tran, Melanie; Fernandez-Rojo, Manuel MA; Merry, Troy TL; Zhang, Xinmei; Xu, Yang; Fukushima, Atsushi; Waters, Jonathan Michael; Watt, Matthew J; Andrikopoulos, Sofianos; Neel, Benjamin BG; Tiganis, Tony
Informations sur la publication:	Cell Metabolism, 20, 1, page (85-102)
Statut de publication:	Publié, 2014-07
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Animals
	Cells, Cultured
	Diet, High-Fat
	Female
	Glutathione Peroxidase -- deficiency -- genetics -- metabolism
	Growth Hormone -- metabolism
	Hepatocytes -- cytology -- metabolism
	Insulin -- metabolism -- pharmacology
	Insulin-Like Growth Factor I -- metabolism
	Liver -- enzymology -- metabolism
	Male
	Mice
	Mice, Inbred C57BL
	Mice, Knockout
	Obesity -- metabolism -- pathology
	Oxidative Stress
	Protein Tyrosine Phosphatase, Non-Receptor Type 2 -- deficiency -- genetics -- metabolism
	Reactive Oxygen Species -- metabolism
	STAT1 Transcription Factor -- metabolism
	STAT3 Transcription Factor -- metabolism
	STAT5 Transcription Factor -- genetics -- metabolism
	Signal Transduction -- drug effects
Langue:	Anglais
Identificateurs:	urn:issn:1550-4131
	info:doi/10.1016/j.cmet.2014.05.011
	info:pii/S1550-4131(14)00219-8
	info:pmid/24954415
	PMC4335267