par Body, Jean-Jacques ;Quinn, Geoffrey;Talbot, Susan;Booth, Emma;Demonty, Gaston ;Taylor, Aliki;Amelio, Justyna
Référence Critical reviews in oncology/hematology, 115, page (67-80)
Publication Publié, 2017-07
Référence Critical reviews in oncology/hematology, 115, page (67-80)
Publication Publié, 2017-07
Article révisé par les pairs
Résumé : | A systematic literature review was conducted to quantify populations of patients with primary breast cancer in whom bone metastases were detected at study start or during follow-up. Searches were performed in PubMed and EMBASE using terms related to breast cancer and bone metastases. Articles had to have been published 01/01/99–31/12/13, and to report data on the proportion of patients with bone metastases among patients with breast cancer. In total, 156 articles were included in the meta-analysis. A median of 12% of patients with stage I–III breast cancer developed bone metastases during a median follow-up of 60 months. Of patients who developed metastatic disease during follow-up, 55% (median) had bone metastases. Of those with metastatic breast cancer at study start, 58% (median) had bone metastases. These data help to inform on the global burden of bone metastases by defining patient populations that are at risk of developing bone metastases. |