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Comparison between the in vitro interaction of lectins (PHA and Con A) and antimicrococcus antibodies on normal and malignant cells

par Verloes, René;Atassi, Ghanem ;Kanarek, Louis
Référence European journal of cancer, 15, 12, page (1439-1448)
Publication Publié, 1979

Article révisé par les pairs

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Résumé :

Rabbit sera and purified antibodies directed against Micrococcus lysodeikticus (a Gram-positive, non-pathogenic and easy-to-eliminate bacterium) do not bind at 37°C to autologous, isologous or heterologous (mouse and human) erythrocytes, as measured by agglutination assays, heterologous (guinea pig) complement cytotoxicity or Coombs test reactivity. However, rabbit and mice antimicrococcus sera agglutinate Ehrlich carcinoma cells and human leucocytes. Both lectins, Con A and PHA, agglutinate Ehlrich carcinoma cells, human leucocytes and erythrocytes of different species but only ConA is able to agglutinate Micrococcus cells. Biological effects of cell surface binding are discussed. © 1979.