par Gingras, Isabelle;Santarpia, Libero;Ignatiadis, Michail 
Référence Molecular Pathology of Breast Cancer, Springer International Publishing, page (235-256)
Publication Publié, 2016-01
Référence Molecular Pathology of Breast Cancer, Springer International Publishing, page (235-256)
Publication Publié, 2016-01
Partie d'ouvrage collectif
| Résumé : | Circulating nucleic acids such as DNA and microRNA are released and circulate in the blood of cancer patients. In breast cancer, free circulating nucleic acids are being explored as potential blood biomarkers for real-time tumor monitoring. In the past decades, increasing evidence has emerged indicating potential use of circulating DNA for assessment of tumor burden and for tumor genomic and epigenetic profiling. MicroRNA profiling studies also suggest potential utility for breast cancer screening, prognosis evaluation and interrogating mechanisms of therapy resistance and tumor biology. However, a variety of preanalytical considerations must be contemplated and ultimately clinical validity and utility must be demonstrated. This book chapter will explore the main methods to detect and analyze circulating tumor DNA and circulating microRNA, and the clinical applications for circulating free nucleic acids analysis in breast cancer. |
