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Histological transformation of ALK rearranged adenocarcinoma into small cell lung cancer: A new mechanism of resistance to ALK inhibitors

par Levacq, Delphine ;D'Haene, Nicky ;De Wind, Roland;Remmelink, Myriam ;Berghmans, Thierry
Référence Lung cancer, 102, page (38-41)
Publication Publié, 2016-12

Article révisé par les pairs

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Résumé :

Various mechanisms of resistance to ALK inhibitors in ALK rearranged adenocarcinomas are reported including secondary gatekeeper mutations, bypass signaling or ALK amplifications as the commonest ones. We report a new mechanism of resistance with transformation of adenocarcinoma into small cell lung cancer. A 53-year-old non-smoker woman, experienced cancer progression after two lines of ALK inhibitors. A new biopsy showed a small cell lung cancer. FISH revealed persistent ALK rearrangement with an atypical pattern and complete loss of the 5′ region of the ALK gene.