par Bonnyns, Marc 
;Pasteels, Jean Lambert ;Herlant, Marc ;Vanhaelst, Luc ;Bastenie, Paul Auguste
Référence The Journal of clinical endocrinology and metabolism, 35, 5, page (722-728)
Publication Publié, 1972
;Pasteels, Jean Lambert ;Herlant, Marc ;Vanhaelst, Luc ;Bastenie, Paul Auguste Référence The Journal of clinical endocrinology and metabolism, 35, 5, page (722-728)
Publication Publié, 1972
Article révisé par les pairs
| Résumé : | TSH has been measured by bioassay in 22 pituitaries of patients with asymptomatic thyroiditis matched for age, sex and concomitant diseases with 18 pituitaries of control subjects. The mean TSH concentration was significantly increased in the thyroiditis pituitaries. Accordingly, the thyrotropes were increased in number and size, partially degranulated, with a dilated Golgi area and a large nucleolus. In a double-blind study performed on 8 cases, such morphologic evidence of thyrotropic activity was well correlated with a high TSH concentration. These observations provide evidence of hypertrophy of the thyrotropes along with increased TSH concentration in the hypophyses of asymptomatic thyroiditis cases. © 1972 by The Endocrine Society. |
