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Synthesis and evaluation of novel N‐substituted N′‐(3‐hydroxy‐17‐oxoestra‐1,3,5(10)‐trien‐2‐ and ‐4‐yl)thiourea derivatives for binding to the estrogen receptor and cytotoxic activity on mcf‐7 cells

par Omar, AMME Mohsen M E A.‐.M.E.;Aboulwafa, Omaima O.M.;Leclercq, Guy
Référence Journal of pharmaceutical sciences, 73, 12, page (1871-1873)
Publication Publié, 1984

Article révisé par les pairs

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Résumé :

A novel series of estrone derivatives having a free 3‐phenolic group with the 2‐ or 4‐position substituted with a thiourea function was synthesized. None of the products showed significant binding to the estrogen receptor, and the cytotoxic activity on MCF‐7 cells for VII and X was weak. Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company