par Verloes, René;Atassi, Ghanem 
;Dumont, Patrick ;Kanarek, Louis
Référence British Journal of Cancer, 38, 5, page (599-605)
Publication Publié, 1978
;Dumont, Patrick ;Kanarek, LouisRéférence British Journal of Cancer, 38, 5, page (599-605)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | A comparative study of the effects of BCG, Micrococcus lysodeikticus, and a series of structurally related polysaccharides (complement triggers) on the nonspecific and specific immune resistance against L1210 lymphoid leukaemia was carried out and commented on. In contrast with authors of earlier reports, we were unable to generate any effective non-specific or specific immunotherapy after the graft of 104 leukaemic cells to 8-10-week-old CDF1 mice. However, when mice were prevaccinated with irradiated (8 krad X-rays) cultured cells combined with 1 mg of bacterium or polysaccharide one month before grafting 104 cells, they were given an immunoprotection that was more pronounced with the i.p. than with the i.v. route. Prevaccinated mice were afforded a stronger immunoprotection when boosted repeatedly with lmg injections of bacterium or polysaccharide after tumour challenge. © 1978, Cancer Research Campaign. All rights reserved. |
