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LC-MS analysis combined with principal component analysis and soft independent modelling by class analogy for a better detection of changes in N-glycosylation profiles of therapeutic glycoproteins.

par Planinc, Ana ;Dejaegher, Bieke ;Vander Heyden, Yvan;Viaene, Johan;Van Praet, Serge ;Rappez, Florence;Van Antwerpen, Pierre ;Delporte, Cédric
Référence Analytical and Bioanalytical Chemistry
Publication Publié, 2017-01

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Titre:	LC-MS analysis combined with principal component analysis and soft independent modelling by class analogy for a better detection of changes in N-glycosylation profiles of therapeutic glycoproteins.
Auteur:	Planinc, Ana; Dejaegher, Bieke; Vander Heyden, Yvan; Viaene, Johan; Van Praet, Serge; Rappez, Florence; Van Antwerpen, Pierre; Delporte, Cédric
Informations sur la publication:	Analytical and Bioanalytical Chemistry
Statut de publication:	Publié, 2017-01
Sujet CREF:	Sciences bio-médicales et agricoles
	Sciences pharmaceutiques
	Analyse et contrôle pharmaceutique
	Chimie analytique
Mots-clés:	High-resolution mass spectrometry (HRMS)
	Hydrophilic interaction liquid chromatography (HILIC)
	N-Glycans
	Principal component analysis (PCA)
	Soft independent modelling by class analogy (SIMCA)
	Therapeutic glycoproteins
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:1618-2642
	info:doi/10.1007/s00216-016-9683-9
	info:pii/10.1007/s00216-016-9683-9
	info:scp/84973636833
	info:pmid/27287011