Inflammation induced by inhaled lipopolysaccharide depends on particle size in healthy volunteers.

Doyen, Virginie; Pilcer, Gabrielle; Dinh, Duc Huy Phong; Corazza, Francis; Bernard, Alfred; Bergmann, Pierre; Lefevre, Nicolas; Amighi, Karim; Michel, Olivier

doi:doi/10.1111/bcp.13052

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Inflammation induced by inhaled lipopolysaccharide depends on particle size in healthy volunteers.

par Doyen, Virginie

;Pilcer, Gabrielle

;Dinh, Duc Huy Phong

;Corazza, Francis

;Bernard, Alfred ;Bergmann, Pierre

;Lefevre, Nicolas

;Amighi, Karim

;Michel, Olivier

Référence British journal of clinical pharmacology, 82, 5, page (1371-1381)
Publication Publié, 2016-06

Article révisé par les pairs

Résumé :

In drug development, lung anti-inflammatory properties of new molecules are currently tested on the inhaled LPS model. The total and regional lung bioavailability of inhaled particles depends significantly on their size. The objective was to compare inflammatory responses in healthy volunteers after the inhalation of lipopolysaccharide (LPS) of varying droplet size.

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