par Fery, Françoise 
;Balasse, Edmond
Référence Revue Francaise d'Endocrinologie Clinique - Nutrition et Metabolisme, 38, 6, page (547-554)
Publication Publié, 1997
;Balasse, Edmond Référence Revue Francaise d'Endocrinologie Clinique - Nutrition et Metabolisme, 38, 6, page (547-554)
Publication Publié, 1997
Article révisé par les pairs
| Résumé : | The present study aims at characterizing the kinetics and pathways of glucose utilization (oxidation vs storage) in non-insulin-dependent diabetic (NIDDM) patients both in the basal state and during a 75 g oral glucose tolerance test (OGTT). Therefore, 15 NIDDM patients and 15 control subjects were tested with a dual tracer technique (primed constant i.v. infusion of 6-3H-glucose and 1-14C-glucose incorporated in the oral load) combined with indirect calorimetry. In the basal state, the diabetic patients had elevated rates of glucose production and uptake, the latter being entirely accounted for by an increase in the nonoxidative pathway compatible with an acceleration of the Cori cycle. In the NIDDM patients, during the initial 2 hours following glucose ingestion, tissular glucose disposal was impaired in relation to a reduction in glucose storage. However, the persistance of higher plasma glucose levels beyond 2 hours brought about a normalization of the amount of glucose taken up by the tissues as well as the intracellular pathways of glucose metabolism. Taking into account the data of the literature, it is likely that the selective impairment of glucose storage observed during the early postprandial period can simply be accounted for by the reduced uptake and does not necessarily imply the existence of a specific defect in glycogen synthesis. |
