par Gescher, Andreas;Gibson, Neil N.W.;Hickman, John J.A.;Langdon, Simon S.P.;Ross, David Anthony D.;Atassi, Ghanem 
Référence British Journal of Cancer, 45, 6, page (843-850)
Publication Publié, 1982
Référence British Journal of Cancer, 45, 6, page (843-850)
Publication Publié, 1982
Article révisé par les pairs
| Résumé : | The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had no significant activity. N-methylformamide and N-ethylformamide were equitoxic to the TLX5 lymphoma in vitro. Formamide was found as a metabolite in the plasma and urine of animals given N-methylformamide and N-ethylformamide, but excretion profiles do not support the hypothesis that formamide is an active antitumour species formed from N-alkylformamides. No appreciable metabolism of N-methylformamide occurred under a variety of conditions with liver preparations in vitro. N-methylformamide, but not N-ethylformamide or formamide, reduced liver soluble non-protein thiols by 59.8% 1 h after administration of an effective antitumour dose. © 1982 Cancer Research Campaign. All rights reserved. |
