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Identification of compounds with anti-proliferative activity from the wood of Ficus elastica Roxb. ex Hornem. aerial roots.

par Mbosso, Emmanuel Jean Teinkela;Noundou, Xavier Siwe;Nguemfo, Edwige Laure;Meyer, Franck ;Djoukoue, Alfred;Van Antwerpen, Pierre ;Ngouela, Silvère;Tsamo, Etienne;Mpondo, Emmanuel Albert Mpondo EA;Vardamides, Juliette Cathérine;Azebaze, Guy Anatole Blaise;Wintjens, René
Référence Fitoterapia, 112, page (65)
Publication Publié, 2016-05

Article révisé par les pairs

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Résumé :

The natural products fromplants still remain an important source of pharmaceuticals. In the current study, methanolicwood extracts of Ficus elastica Roxb. ex Hornem. (Moraceae) aerial roots were screened for anti-cancer activity. Using bioassay-guided fractionation, three new compounds, elasticamide (1), elastiquinone (2) and ficusoside B (3), together with four known compounds, were isolated. The structures of the new compounds were established by means of extensive spectroscopic analyses (1D and 2D NMR, HR-ESI-MS, as well as IR and UV) and by comparison of their spectroscopic data with those reported for structurally related molecules. The isolated compounds were afterwards evaluated for their anti-proliferative effect on six human cancer cell lines (U373n and Hs683 glioblastoma, MCF7 and A549 NSCLC carcinoma, and B16F10 and SK-MEL-28 melanoma) using colorimetric MTT assay. Most notably, elastiquinone (2) showed cytotoxic activity with IC50 = 14 μM against B16F10 melanoma cells, whereas the peracetylated form of ficusoside B (3a) displayed the lowest IC50 value (11 μM) against U373n gliomacell lines. Elasticamide (1) and ficusoside B (3) exhibited aweak cytotoxicity with IC50 values ≥88 μM. The results of this investigation demonstrate that the wood of F. elastica aerial roots might be a potential source for identifying new compounds with potent anti-proliferative activity.