par Manicourt, Daniel 
;Orloff, Serge
Référence Acta rhumatologica, 2, 1-2, page (5-21)
Publication Publié, 1978
;Orloff, Serge Référence Acta rhumatologica, 2, 1-2, page (5-21)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | Report on the case history of osteomalacia in a young female patient with megaduodenum and blind loop syndrome. Congenital megaduodenum was considered as the most probable diagnosis in the absence of any convincing evidence in favor of other etiologies and in presence of a megaduodenum associated with megaoesophagus in the patient's father. Correction of vitamin D malabsorption by administration of appropriate antibiotics stresses the role of massive intraluminal bacterial overgrowth either through direct destruction of vitamin D or through decreased micellar solubilisation due to deconjugation of biliary acids. The importance of cutaneous vitamin D synthesis for patients with osteomalacia of digestive origin is recalled. The association of megaoesophagus with megaduodenum as described in the patient's father is thought to be the first such case ever described. |
