• Citer

Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence.

par Peirs, Priska ;Lefèvre, Philippe ;Boarbi, Samira ;Wang, Xiao-Ming ;Denis, Olivier ;Braibant, Martine ;Pethe, Kevin;Locht, Camille ;Huygen, Kris ;Content, Jean
Référence Infection and immunity, 73, 3, page (1898-1902)
Publication Publié, 2005-03

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

By measuring phosphate uptake by Mycobacterium tuberculosis strains with the pstS1 and pstS2 genes genetically inactivated, we showed that these pstS genes encode high-affinity phosphate binding proteins. In a mouse infection model, both mutants were attenuated in virulence, suggesting that M. tuberculosis encounters limiting phosphate concentrations during its intracellular life span.