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PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

par Moore, Fabrice ;Colli, Maikel Luis ;Cnop, Miriam ;Igoillo Esteve, Mariana ;Cardozo, Alessandra K ;Andrade Da Cunha, Daniel ;Bugliani, Marco;Marchetti, Piero;Eizirik, Decio
Référence Diabetes (New York, N.Y.), 58, 6, page (1283-1291)
Publication Publié, 2009-06

Article révisé par les pairs

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Résumé :

The pathogenesis of type 1 diabetes has a strong genetic component. Genome-wide association scans recently identified novel susceptibility genes including the phosphatases PTPN22 and PTPN2. We hypothesized that PTPN2 plays a direct role in beta-cell demise and assessed PTPN2 expression in human islets and rat primary and clonal beta-cells, besides evaluating its role in cytokine-induced signaling and beta-cell apoptosis.