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Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

par Andrade Da Cunha, Daniel ;Ladrière, Laurence ;Ortis, Fernanda ;Igoillo Esteve, Mariana ;Gurzov, Esteban Nicolas ;Lupi, Roberto;Marchetti, Piero;Eizirik, Decio ;Cnop, Miriam
Référence Diabetes (New York, N.Y.), 58, 12, page (2851-2862)
Publication Publié, 2009-12

Article révisé par les pairs

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Résumé :

Chronic exposure of pancreatic beta-cells to saturated free fatty acids (FFAs) causes endoplasmic reticulum (ER) stress and apoptosis and may contribute to beta-cell loss in type 2 diabetes. Here, we evaluated the molecular mechanisms involved in the protection of beta-cells from lipotoxic ER stress by glucagon-like peptide (GLP)-1 agonists utilized in the treatment of type 2 diabetes.