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Étude de la spectinomycine et de la benzyl-penicilline procaine dans les urethrites gonococciques

par Thiry, Andre-Jacques ;Weiser, M.
Référence Acta therapeutica, 3, 4, page (313-318)
Publication Publié, 1977

Article révisé par les pairs

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Résumé :

The authors have performed a randomized comparative study with spectinomycin and procaine benzylpenicillin in the treatment of gonorrheal urethritis. The study included 100 patients. The investigations needed for the evaluation of efficacy and toleration could be performed in 81 of them (38 were belonging to the spectinomycin group and 43 to the benzylpenicillin group). The cure rate was 97.9% after treatment with benzylpenicillin and 94.7% with spectinomycin. These results were obtained with a single dose of 4.800.000 U. benzylpenicillin and 2 g. of spectinomycin in men or 4 g. spectinomycin in women. Since both treatments provide equal results it seems appropriate to prefer spectinomycin in view of the rarity of allergic reactions and side-effects.