par Maccari, Stefania 
;Van Reeth, Olivier
Editeur scientifique Fink, George
Référence Encyclopedia of Stress, Academic Press, Ed. 2, page (505-508)
Publication Publié, 2007
;Van Reeth, Olivier Editeur scientifique Fink, George
Référence Encyclopedia of Stress, Academic Press, Ed. 2, page (505-508)
Publication Publié, 2007
Partie d'ouvrage collectif
| Résumé : | Prenatal stress (PNS) can induce persistent changes in the development of the individual. PNS increases anxiety-like behaviors and induces changes in the hypothalamic-pituitary-adrenal (HPA) axis in adult rats. Because adaptive capabilities also depend on temporal organization and synchronization with the external environment, we studied the effects of PNS on circadian rhythms, including the sleep-wake cycle. Using a gestational restraining procedure, we showed that PNS induced phase advances in hormonal/behavioral circadian rhythms in adult rats and an increase in the amount of paradoxical sleep that was positively correlated to plasma corticosterone levels. Using gestational hypoxia, we showed that prenatal hypoxia might change synchronizing properties of the circadian system. Because depressed patients exhibit changes in circadian rhythmicity and paradoxical sleep regulation, we suggest that PNS could represent an original animal model for studies of depression. © 2007 Copyright © 2007 Elsevier Inc. All rights reserved. |
