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Sustained release solid dispersions of indomethacin with Eudragit RS and RL

par Oth, Marianne P. ;Moes, André Jules
Référence International journal of pharmaceutics, 55, 2-3, page (157-164)
Publication Publié, 1989-10

Article révisé par les pairs

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Résumé :

Sustained release solid dispersions have been investigated using Eudragit RS and Eudragit RL as carriers and indomethacin as a model drug. The solid dispersions were prepared by the solvent method. Up to 30% and up to 20% indomethacin can be dispersed amorphously in Eudragit RL and Eudragit RS respectively. The release profiles of the drug can be fitted to the square-root of time model. Coevaporates prepared with Eudragit RS give slower release rates than those prepared with Eudragit RL. By increasing the particle size from 100 to 630 μm, the release rate can be reduced. By blending Eudragit RS and Eudragit RL, the kinetics of release can be modulated. There is a linear relationship between the Higuchi rate constant and the percentage of Eudragit RL in a Ind/RS/RL mixture. The influence of pH was studied showing that coevaporates with lower sensitivity to pH variation can be prepared. Interactions between indomethacin and Eudragit RL were investigated and were found to follow a type 1 Langmuir isotherm. The tabletting properties of coevaporates were studied and show no influence of tabletting forces on the Higuchi's release rate constant. © 1989.