par Sundblad, Victoria;Rabinovich, Gabriel Adrián;Mathieu, Véronique ;Kiss, Robert
Référence Cancer Immunotherapy: Immune Suppression and Tumor Growth: Second Edition, Elsevier Inc., page (537-563)
Publication Publié, 2013-07
Partie d'ouvrage collectif
Résumé : Galectins are glycan-binding proteins implicated in intracellular signaling, cell-cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key players in the tumor microenvironment. They are expressed and released by different cell types, including tumor, stromal, endothelial and immune cells. Galectins critically influence tumor progression by modulating tumor cell migration, invasiveness, angiogenesis and antitumor immune responses. Intracellularly, galectins modulate survival and proliferation and they interact with a variety of signaling pathways. Given these extracellular and intracellular functions and their regulated expression at sites of tumor growth and metastasis, galectins have stimulated great interest as relevant biomarkers and novel targets in cancer therapy. © 2013 Elsevier Inc. All rights reserved.