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Beneficial effects of a fish oil diet for the correction of the fatty acid pattern of intestinal, liver, red blood cells, brain and adipose tissue lipids in rats deprived of long-chain polyunsaturated ω3 fatty acids

par Malaisse, Willy ;Carpentier, Yvon
Référence Fish Oil: Production, Consumption and Health Benefits, Nova Science Publishers, Inc., page (107-135)
Publication Publié, 2012-02

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Résumé :

The initial aim of the present chapter was to assess the suitability of a fish oil diet to correct the metabolic and hormonal defects otherwise encountered in rats deprived of a dietary supply of long-chain polyunsaturated ω3 fatty acids. For such a purpose, 8 groups of 4 rats each were first exposed from the 8th week after birth and for the ensuing 3 months to either a soya oil or sunflower oil diet and then examined at the end of this 3 months initial period or after a further period of one, two or 8 weeks exposure to a fish oil diet. The fatty acid profile of jejunum, caecum, liver, red blood cells and brain phospholipids, as well as liver triglycerides and visceral adipose tissue lipids, was analyzed. Changes in food intake, body weight and the HOMA index for insulin resistance were also monitored. The results document the efficiency of this procedure for the correction of both the ω3 deficiency and insulin resistance, without any undesirable increase in liver steatosis, visceral obesity, food intake or body weight. Emphasis is also placed on the dual regulation of the lipid fatty acid profile as attributable to either a direct link with the fatty acid content of the diet or the transfer of information from one organ to another.©2012 Nova Science Publishers, Inc.