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Influence of protamine on the susceptibility of Pseudomonas aeruginosa to cefotaxime, sulphadimethoxine, polymyxin B and some β-lactam antibiotics

par Boussard, Paule ;Crotteux, Jeanne
Référence International journal of pharmaceutics, 46, 1-2, page (45-48)
Publication Publié, 1988

Article révisé par les pairs

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Résumé :

Protamine, a basic protein, was shown to influence the activity of antibacterial agents. When added to tryptic soy broth it enhanced the bactericidal activity of cefotaxime, sulphadimethoxine, ticarcillin, piperacillin and carbenicillin against Pseudomonas aeruginosa. In contrast, the activity of polymyxin B against this species was markedly reduced in the presence of protamine. © 1988.