par Milaire, Jean 
Référence Bulletin et mémoires de l'Académie royale de médecine de Belgique, 133, 7, page (402-415)
Publication Publié, 1978
Référence Bulletin et mémoires de l'Académie royale de médecine de Belgique, 133, 7, page (402-415)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | The experimental and descriptive studies of the genesis of limb anomalies have revealed a great diversity of the mechanisms by which a primary teratogenic lesion, either genic or exogenous, can modify, frequently by indirect ways, the genesis of the skeletal segments. If most anomalies of genetic origin can be related to specific disturbances of the basic morphogenetic processes which control normal development, those experimentally induced in animals involve non specific alterations affecting the cellular vitality of the undifferentiated or of the early differentiating mesoderm the vascularization or innervation of the limb buds, some mechanical conditions and, less frequently, the biochemical processes of chondrogenesis. In both cases, the final anomaly is often the result of a compromise between the extent or the severity of the primary lesions and the degree of effectiveness of the regulatory mechanisms capable of correcting or compensating the structural defects. |
