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High performance liquid chromatographic capacity factor and partition coefficient relationship in a benzamide series

par Verbiese-Genard, N.;Hanocq, Michel ;Van Damme, Marc ;Molle, Léopold
Référence International journal of pharmaceutics, 9, 4, page (295-303)
Publication Publié, 1981

Article révisé par les pairs

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Résumé :

High performance liquid chromatography was used to establish the relationship between capacity factor (log k') and partition coefficient (log P octanol/water) in a benzamides series. The Chromatographie parameter was correlated to log P values experimentally determined by the shake-flask method and to log P calculated from Rekker's molecular fragments approach. In both cases, for the 10 molecules studied, capacity factor on partition coefficient fit very closely a regression line. The linear model was tested for another molecule in the same series. When comparing the computed values and the experimental ones, it can be concluded that HPLC is a good tool in predicting partition coefficient in this series. © 1981.