par Gergely, Judith ;Hechtermans, R.
Référence Revue Francaise de Gynecologie et d'Obstetrique, 69, 12, page (721-729)
Publication Publié, 1974
Article révisé par les pairs
Résumé : The hypothalamo hypophyseal control of gonadotrophin function involves complex mechanisms, the study of which requires animal experimentation. In addition, determination of the hypothalamic hormones releasing LH and FSH is only at an early stage of development. If the principal factor regulating the functioning of the hypothalamus is the level of estrogens, as is indicated by numerous experimental data, including information provided by use of antiestrogenic substances, then the roles of progesterone and of neurohormonal mediators, such as dopamine, should be taken into consideration. The control of hypophyseal gonadotrophin function is exercised by the hypothalamic releasing hormones, but the modalities of the response are greatly dependent not only on the level of estrogens, but also on the level of progesterone. The numerous experimental results that have led to these conclusions are analysed critically, as are the fragments of information at present available on the biochemical modes of action of the releasing hormones on the hypophyseal cells.