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Inhibition of angiotensin-induced contractions of guinea-pig isolated ileum by high concentrations of non-steroidal antiinflammatory drugs and various steroids and its reversal by prostaglandin E1

par Famaey, Jean Pierre ;Fontaine, Jeanine ;Seaman, Isabelle;Reuse, Joannes
Référence Prostaglandins, 16, 5, page (725-732)
Publication Publié, 1978

Article révisé par les pairs

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Résumé :

Nine non-steroidal antiinflammatory drugs, five steroidal antiinflammatory drugs and four sex steroids were found to potently and reversibly inhibit angiotensin-induced contractions of guinea-pig isolated ileum. The effects of these drugs were reversed by small amounts of PGE1 but the mechanism of their action was probably non selective for angiotensin. © 1978.